{"id":2668,"date":"2023-09-25T10:21:51","date_gmt":"2023-09-25T10:21:51","guid":{"rendered":"https:\/\/blogs.cardiff.ac.uk\/centre-for-trials-research\/?p=2668"},"modified":"2023-09-25T10:27:55","modified_gmt":"2023-09-25T10:27:55","slug":"raising-awareness-of-pad-pain-and-vascular-disease-the-placement-trial","status":"publish","type":"post","link":"https:\/\/blogs.cardiff.ac.uk\/centre-for-trials-research\/raising-awareness-of-pad-pain-and-vascular-disease-the-placement-trial\/","title":{"rendered":"Raising Awareness Of PAD, Pain And Vascular Disease: The PLACEMENT Trial"},"content":{"rendered":"<p style=\"font-weight: 400\">This month is peripheral arterial disease (PAD) awareness month, vascular disease awareness month and pain awareness month. The number of adults with age-related chronic diseases, including PAD\/vascular disease, is increasing worldwide. Similarly, the number of adults who undergo leg amputation surgery for PAD\/vascular disease in the UK is increasing each year. Pain experienced after leg amputation surgery is a leading cause of patient dissatisfaction and a barrier to their rehabilitation, which may affect their recovery. The management of patient\u2019s pain is therefore important for them to achieve their short- and long-term goals after amputation surgery. We held a discussion group with amputees who helped us design this trial by telling us what is important to them about amputation pain. The Perineural Local Anaesthetic Catheter After Major Lower Limb Amputation Trial (<a href=\"https:\/\/www.cardiff.ac.uk\/centre-for-trials-research\/research\/studies-and-trials\/view\/placement\" target=\"_blank\" rel=\"noopener\">PLACEMENT<\/a>) has been designed to compare postoperative pain in two groups of people undergoing leg amputation surgery for PAD\/vascular disease.<\/p>\n<figure id=\"post-2669 media-2669\" class=\"image align-center\"><img decoding=\"async\" src=\"http:\/\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-content\/uploads\/sites\/499\/2023\/09\/PLACEMENT-Blog-Summary-Slide.png\" alt=\"\" \/><\/figure>\n<h2 style=\"font-weight: 400\">What is planned?<\/h2>\n<p style=\"font-weight: 400\">650 patients with planned leg amputations for PAD\/vascular disease will be recruited from 14 UK NHS sites, including eight lead sites. Cardiff and Vale University Health Board is the lead site, with their Principal Investigator, David Bosanquet, also the Chief Investigator of the trial. The seven other lead sites include Bristol, Swansea, Imperial, Leicester, Newcastle, Hull and Cambridge. Cardiff and Vale and Leicester have had their site initiation visits in the last two weeks, and we hope to initiate the remaining six lead sites over the next four weeks.<\/p>\n<p style=\"font-weight: 400\">At the time of their leg amputation surgery, participants will be randomised to either receive a perineural nerve catheter (PNC) or not. A PNC is a thin plastic tube, placed next to the main leg nerve which is cut during amputation surgery. Participants randomised to receive the PNC will have a local anaesthetic infused for the first five days after leg amputation surgery. All participants will receive additional pain-management medications as required. The primary aim of PLACEMENT is to evaluate if the use of a PNC with continuous local anaesthetic infusion, affects the amount of pain participants experience, compared to no PNC. Secondary aims include assessing the effect of PNC use on participant satisfaction of pain management, and recovery at 3 and 6 months, including chronic pain, wound healing, quality of life, time to achieve prosthesis fitting and level of independence.<\/p>\n<h2 style=\"font-weight: 400\">Recommendations for researchers<\/h2>\n<p style=\"font-weight: 400\">The findings from this research will be presented at medical conferences, published in free to access medical journals, and shared with people who write amputation surgery guidelines and policies. We will share the trial results via the national press, amputation charities and social media, including the PLACEMENT Twitter and website pages. Our patient and public involvement (PPI) group will work with us throughout the trial and help prepare a summary of the results. Two members of the public are a central part of our research team. One has had two amputations, one with and one without a PNC. Our other member lost her father after an amputation. Both helped us plan and run the PLACEMENT Feasibility trial and plan this larger trial.<\/p>\n","protected":false},"excerpt":{"rendered":"This month is peripheral arterial disease (PAD) awareness month, vascular disease awareness month and pain awareness month. The number of adults with age-related chronic diseases, including PAD\/vascular disease, is increasing [&hellip;]","protected":false},"author":6999,"featured_media":2674,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[7],"tags":[],"class_list":["post-2668","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-events"],"jetpack_publicize_connections":[],"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p7dIou-H2","jetpack-related-posts":[{"id":2970,"url":"https:\/\/blogs.cardiff.ac.uk\/centre-for-trials-research\/improving-lives-through-research-for-vascular-disease-and-pain-management-clarity-and-placement-trials\/","url_meta":{"origin":2668,"position":0},"title":"Improving Lives Through Research for Vascular Disease and Pain Management: CLARITY and PLACEMENT Trials","author":"Cherry-Ann Waldron","date":"September 20, 2024","format":false,"excerpt":"- by Grace Young, Waku Maboshe \u00a0and Cherry-Ann Waldron September is pain awareness month, peripheral arterial disease (PAD) awareness month and vascular disease awareness. The number of adults with age-related chronic diseases, including PAD\/vascular disease, is increasing worldwide. Similarly, the number of adults who undergo revascularisation or amputation surgery for\u2026","rel":"","context":"In &quot;Events&quot;","block_context":{"text":"Events","link":"https:\/\/blogs.cardiff.ac.uk\/centre-for-trials-research\/category\/events\/"},"img":{"alt_text":"Surgeons performing surgery.","src":"https:\/\/i0.wp.com\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-content\/uploads\/sites\/499\/2024\/09\/Surgeons-performing-surgery.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-content\/uploads\/sites\/499\/2024\/09\/Surgeons-performing-surgery.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-content\/uploads\/sites\/499\/2024\/09\/Surgeons-performing-surgery.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-content\/uploads\/sites\/499\/2024\/09\/Surgeons-performing-surgery.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-content\/uploads\/sites\/499\/2024\/09\/Surgeons-performing-surgery.jpg?resize=1050%2C600&ssl=1 3x"},"classes":[]},{"id":2849,"url":"https:\/\/blogs.cardiff.ac.uk\/centre-for-trials-research\/limb-loss-and-limb-difference-awareness-month-2024\/","url_meta":{"origin":2668,"position":1},"title":"Limb Loss and Limb Difference Awareness Month 2024","author":"Grace Young","date":"March 27, 2024","format":false,"excerpt":"-By Sarah Milosevic and Grace Young April is Limb Loss and Limb Difference Awareness month. Losing a limb is a life-changing event. The number of people undergoing leg amputation surgery in the UK has risen from 3,260 in 2019 to 3,430 in 20221. This increase in the number of leg\u2026","rel":"","context":"In &quot;Events&quot;","block_context":{"text":"Events","link":"https:\/\/blogs.cardiff.ac.uk\/centre-for-trials-research\/category\/events\/"},"img":{"alt_text":"PLACEMENT Infographic FINAL created on 19th October 2023.","src":"https:\/\/i0.wp.com\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-content\/uploads\/sites\/499\/2024\/03\/PLACEMENT-Infographic-FINAL-V1.1-19102023.png?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-content\/uploads\/sites\/499\/2024\/03\/PLACEMENT-Infographic-FINAL-V1.1-19102023.png?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-content\/uploads\/sites\/499\/2024\/03\/PLACEMENT-Infographic-FINAL-V1.1-19102023.png?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-content\/uploads\/sites\/499\/2024\/03\/PLACEMENT-Infographic-FINAL-V1.1-19102023.png?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-content\/uploads\/sites\/499\/2024\/03\/PLACEMENT-Infographic-FINAL-V1.1-19102023.png?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-content\/uploads\/sites\/499\/2024\/03\/PLACEMENT-Infographic-FINAL-V1.1-19102023.png?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":6618,"url":"https:\/\/blogs.cardiff.ac.uk\/centre-for-trials-research\/celebrating-international-clinical-trials-day-collaboration-in-practice-across-four-trials\/","url_meta":{"origin":2668,"position":2},"title":"Celebrating International Clinical Trials Day: Collaboration in Practice Across Four Trials","author":"Waku Maboshe","date":"May 20, 2026","format":false,"excerpt":"Authors: Waku Maboshe, Ben Karatas, Melanie Varley and Grace Young As we mark International Clinical Trials Day 2026 and reflect on the Centre for Trials Research (CTR) 10-year anniversary, we are taking a moment, collectively as four trial managers within the infection, inflammation and immunity (I3) Division, to celebrate what\u2026","rel":"","context":"In &quot;Events&quot;","block_context":{"text":"Events","link":"https:\/\/blogs.cardiff.ac.uk\/centre-for-trials-research\/category\/events\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-content\/uploads\/sites\/499\/2026\/05\/i3-Team.png?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-content\/uploads\/sites\/499\/2026\/05\/i3-Team.png?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-content\/uploads\/sites\/499\/2026\/05\/i3-Team.png?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-content\/uploads\/sites\/499\/2026\/05\/i3-Team.png?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-content\/uploads\/sites\/499\/2026\/05\/i3-Team.png?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-content\/uploads\/sites\/499\/2026\/05\/i3-Team.png?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":2002,"url":"https:\/\/blogs.cardiff.ac.uk\/centre-for-trials-research\/get-creactive-raising-awareness-of-adult-hip-dysplasia\/","url_meta":{"origin":2668,"position":3},"title":"Get CreActive &#8211; Raising Awareness of Adult Hip Dysplasia","author":"Julie Latchem-Hastings","date":"February 18, 2021","format":false,"excerpt":"Adult Hip Dysplasia Hip Dysplasia means that the bones of the hip joint are not\u00a0aligned\u00a0properly. It is a general term for hip instability, dislocation, or shallowness of the hip socket. Hip instability and dislocation are more likely to occur in children, while a shallow socket which is stable is more\u2026","rel":"","context":"In &quot;Events&quot;","block_context":{"text":"Events","link":"https:\/\/blogs.cardiff.ac.uk\/centre-for-trials-research\/category\/events\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-content\/uploads\/sites\/499\/2021\/02\/Hip-Dysplasia-Normal-vs-Shallow-Sockets.png?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-content\/uploads\/sites\/499\/2021\/02\/Hip-Dysplasia-Normal-vs-Shallow-Sockets.png?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-content\/uploads\/sites\/499\/2021\/02\/Hip-Dysplasia-Normal-vs-Shallow-Sockets.png?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-content\/uploads\/sites\/499\/2021\/02\/Hip-Dysplasia-Normal-vs-Shallow-Sockets.png?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-content\/uploads\/sites\/499\/2021\/02\/Hip-Dysplasia-Normal-vs-Shallow-Sockets.png?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-content\/uploads\/sites\/499\/2021\/02\/Hip-Dysplasia-Normal-vs-Shallow-Sockets.png?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":2967,"url":"https:\/\/blogs.cardiff.ac.uk\/centre-for-trials-research\/rheumatoid-arthritis-awareness-week-2024-socrates-proms-and-plan-heracles\/","url_meta":{"origin":2668,"position":4},"title":"Rheumatoid Arthritis Awareness Week 2024 \u2013 SOCRATES, PROMs and PLAN-HERACLES","author":"Timothy Pickles","date":"September 16, 2024","format":false,"excerpt":"It is Rheumatoid Arthritis Awareness Week this week (16th to 22nd September 2024), which is organised by the National Rheumatoid Arthritis Society (NRAS). Detail on this can be found here: https:\/\/nras.org.uk\/raaw-24\/ The theme of RA Awareness week 2024 is #STOPtheStereotype, which focusses on dispelling the frustrating stereotypes that surround this\u2026","rel":"","context":"In &quot;Events&quot;","block_context":{"text":"Events","link":"https:\/\/blogs.cardiff.ac.uk\/centre-for-trials-research\/category\/events\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-content\/uploads\/sites\/499\/2024\/09\/SOCRATES.jpg?resize=350%2C200&ssl=1","width":350,"height":200},"classes":[]},{"id":2656,"url":"https:\/\/blogs.cardiff.ac.uk\/centre-for-trials-research\/global-immune-thrombocytopenia-itp-awareness-week-2023\/","url_meta":{"origin":2668,"position":5},"title":"Global Immune Thrombocytopenia (ITP) Awareness Week 2023","author":"Joanna Smith","date":"September 21, 2023","format":false,"excerpt":"September 25-29th 2023 is Global ITP Awareness Week! This specially designated week calls for individuals around the world to join together to promote public awareness of a rare autoimmune disease called immune thrombocytopenia (ITP). The theme for this year\u2019s Global ITP Awareness Week is Increasing Awareness to Improve Outcomes and\u2026","rel":"","context":"In &quot;Events&quot;","block_context":{"text":"Events","link":"https:\/\/blogs.cardiff.ac.uk\/centre-for-trials-research\/category\/events\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-content\/uploads\/sites\/499\/2023\/09\/Global-ITP-Awareness-Week.png?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-content\/uploads\/sites\/499\/2023\/09\/Global-ITP-Awareness-Week.png?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-content\/uploads\/sites\/499\/2023\/09\/Global-ITP-Awareness-Week.png?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-content\/uploads\/sites\/499\/2023\/09\/Global-ITP-Awareness-Week.png?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-content\/uploads\/sites\/499\/2023\/09\/Global-ITP-Awareness-Week.png?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-content\/uploads\/sites\/499\/2023\/09\/Global-ITP-Awareness-Week.png?resize=1400%2C800&ssl=1 4x"},"classes":[]}],"meta_box":[],"jetpack_featured_media_url":"https:\/\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-content\/uploads\/sites\/499\/2023\/09\/PLACEMENT-Logo-2.png","_links":{"self":[{"href":"https:\/\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-json\/wp\/v2\/posts\/2668","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-json\/wp\/v2\/users\/6999"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-json\/wp\/v2\/comments?post=2668"}],"version-history":[{"count":1,"href":"https:\/\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-json\/wp\/v2\/posts\/2668\/revisions"}],"predecessor-version":[{"id":2671,"href":"https:\/\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-json\/wp\/v2\/posts\/2668\/revisions\/2671"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-json\/wp\/v2\/media\/2674"}],"wp:attachment":[{"href":"https:\/\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-json\/wp\/v2\/media?parent=2668"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-json\/wp\/v2\/categories?post=2668"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.cardiff.ac.uk\/centre-for-trials-research\/wp-json\/wp\/v2\/tags?post=2668"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}