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Selective Carbocation Quenching

5 April 2016
GDolS Structure

Our new publication in Biochemistry explores the mechanism of germacradien-4-ol synthase. This enzyme is unusual because water is usually rigorously excluded from the active site to protect the reactive carbocation species. Germacradien-4-ol synthase allows the carbocation to be quenched by water, but with complete selectivity.