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Selecting Against Dynamics

5 April 2016
Image of QM-MM regions used under CC-BY from the RSC journal Chemical Science (DOI: 10.1039/c5sc04209g)

Our new paper in Chemical Science examines the kinetic parameters of dihydrofolate reductase enzymes from different organisms. Whilst some have suggested that dynamic coupling is a key tool for explaining enzyme activity, our results suggests that evolution has actually minimised dynamic effects.