Publications

2020

Accelerating Biphasic Biocatalysis Through New Process Windows
Florence Huynh, Matthew Tailby, Aled Finniear, Kevin Stephens, Rudolf K Allemann, and Thomas Wirth
Angew. Chem. Int. Ed., in press (2020). DOI:10.1002/anie.202005183

Electric Field Measurements Reveal the Pivotal Role of Cofactor-Substrate Interaction in Dihydrofolate Reductase Catalysis
Aduragbemi S. Adesina, Katarzyna Świderek, Louis Y. P. Luk, Vicent Moliner, and Rudolf K. Allemann
ACS Catal., 10, 7907–7914 (2020). DOI:10.1021/acscatal.0c01856

Selective Hydroboration ‐ Oxidation of Terminal Alkenes Under Flow Conditions
Mohamed Elsherbini, Florence Huynh, Alice Dunbabin, Rudolf K. Allemann, and Thomas Wirth
Chem. Eur. J., in press (2020). DOI:10.1002/chem.202001650

Immobilised Enzymes for Sesquiterpene Synthesis in Batch and Flow Systems
Donya Valikhani, Prabhakar L. Srivastava, Rudolf K. Allemann, and Thomas Wirth
ChemCatChem, 12, 2194-2197 (2020). DOI:10.1002/cctc.201902135

Modular Chemoenzymatic Synthesis of Terpenes and their Analogues
Luke A. Johnson, Alice Dunbabin, Jennifer C. R. Benton, Robert J. Mart, Rudolf K. Allemann
Angew. Chem. Int. Ed., 59, 8486-8490 (2020). DOI:10.1002/anie.202001744

An Unexpected Co‐crystal Structure of the Calpain PEF(S) Domain with Hfq Reveals a Potential Chaperone Function of Hfq
Joel Cresser-Brown, Pierre Rizkallah, Yi Jin, Christian Roth, David J. Miller, and Rudolf K. Allemann
Acta. Cryst., F76, 81-85 (2020). DOI:10.1107/S2053230X20001181

Targeted Cell Imaging Properties of a Deep Red Luminescent Iridium (III) Complex Conjugated with a c-Myc Signal Peptide
Adam H. Day, Martin H. Übler, Hannah L. Best, Emyr Lloyd-Evans, Robert J. Mart, Ian A. Fallis, Rudolf K. Allemann, Eman A. H. Al-Wattar, Nathaniel I. Keymer, Niklaas J. Buurma, and Simon J. A. Pope
Chem. Sci., 11, 1599-1606 (2020). DOI:10.1039/C9SC05568A

2019

Harnessing Enzyme Plasticity for the Synthesis of Oxygenated Sesquiterpenoids
Melodi Demiray, David J. Miller, and Rudolf K. Allemann
Beilstein J. Org. Chem., 15, 2184–2190 (2019). DOI:10.3762/bjoc.15.215

“Dark” Singlet Oxygen Made Easy
Mohamed Elsherbini, Rudolf K. Allemann, and Thomas Wirth
Chem. Eur. J., 25, 12486-12490 (2019). DOI:10.1002/chem.201903505

Crystal Structure and Biophysical Analysis of Furfural Detoxifying Aldehyde Reductase from Clostridium beijerinkii
Alan F. Scott, Joel Cresser-Brown, Thomas L. Williams, Pierre J. Rizkallah, Yi Jin, Louis Y.-P. Luk, and Rudolf K. Allemann
Appl. Environ. Microbiol., 85, e00978-19 (2019). DOI:10.1128/AEM.00978-19

A Noncanonical Chromophore Reveals Structural Rearrangements of the Light-Oxygen-Voltage Domain upon Photoactivation
Mindaugas E. Kalvaitis, Luke A. Johnson, Robert J. Mart, Pierre Rizkallah, and Rudolf K. Allemann
Biochem., 58, 2608-2616 (2019). DOI:10.1021/acs.biochem.9b00255

Why Are Some Enzymes Dimers? Flexibility and Catalysis in Thermotoga maritima Dihydrofolate Reductase
J. Javier Ruiz-Pernía, Iñaki Tuñón, Vicent Moliner and Rudolf K. Allemann
ACS Catal., 9, 5902-5911 (2019). DOI:10.1021/acscatal.9b01250

Heavy Enzymes and the Rational Redesign of Protein Catalysts
Alan F. Scott, Louis Y.-P. Luk, Iñaki Tuñón, Vicent Moliner and Rudolf K. Allemann
ChemBioChem, 20, 2807-2812 (2019). DOI:10.1002/cbic.201900134

Cell-penetrating Peptide Sequence and Modification Dependent Uptake and Subcellular Distribution of Green Fluorescent protein in Different Cell Lines
Sanjay G. Patel, Edward J. Sayers, Lin He, Rohan Narayan, Thomas L. Williams, Emily M. Mills, Rudolf K. Allemann, Louis Y. P. Luk, Arwyn T. Jones and Yu-Hsuan Tsai
Sci. Rep., 9, 6298 (2019). DOI:10.1038/s41598-019-42456-8

Silent Catalytic Promiscuity in the High-Fidelity Terpene Cyclase δ-Cadinene Synthase
Marianna Loizzi, David J. Miller, and Rudolf K. Allemann
Org. Biomol. Chem., 17, 1206-1214 (2019). DOI:10.1039/C8OB02821D

2018

Structure-based Design of Allosteric Calpain-1 Inhibitors Populating a Novel Bioactivity Space
Leen Kalash, Joel Cresser-Brown, Johnny Habchi, Connor Morgan, David J. Miller, Robert C. Glen, Rudolf K. Allemann, and Andreas Bender
Eur. J. Med. Chem., 157, 1264-1275 (2018). DOI:10.1016/j.ejmech.2018.08.049

Sesquiterpene Synthase-Catalyzed Conversion of a Farnesyl Diphosphate Analogue to a Nonnatural Terpenoid Ether
Florence Huynh, David J. Miller, and Rudolf K. Allemann
Methods Enzymol., 608, 83-95 (2018). DOI:10.1016/bs.mie.2018.05.004

Sesquiterpene Synthase-Catalysed Formation of a New Medium-Sized Cyclic Terpenoid Ether from Farnesyl Diphosphate Analogues
Florence Huynh, Daniel J. Grundy, Robert L. Jenkins, David J. Miller, and Rudolf K. Allemann
ChemBioChem, 19, 1834-1838 (2018). DOI:10.1002/cbic.201800218

Exploring the Cellular Uptake and Localisation of Phosphorescent Rhenium fac-tricarbonyl Metallosurfactants as a Function of Lipophilicity
Andrew J. Hallett, Emeline Placet, Roxane Prieux, Danielle McCafferty, James A. Platts, David Lloyd, Marc Isaacs, Anthony J. Hayes, Simon J. Coles, Mateusz B. Pitak, Sarah Marchant, Stephen N. Marriott, Rudolf K. Allemann, Athanasia Dervisi and Ian A. Fallis
Dalton Trans., 47, 14241-14253 (2018). DOI:10.1039/c8dt00669e

Isotope Substitution of Promiscuous Alcohol Dehydrogenase Reveals the Origin of Substrate Preference in the Transition State
Enas M. Behiry, J. Javier Ruiz-Pernia, Louis Luk, Iñaki Tuñón, Vicent Moliner and Rudolf K. Allemann
Angew. Chem. Int. Ed., 57, 3128–3131 (2018). DOI:10.1002/anie.201712826

Nucleophilic Water Capture or Proton Loss: Single Amino Acid Switch Converts δ-Cadinene Synthase into Germacradien-4-ol Synthase
Marianna Loizzi, Verónica González, David J. Miller and Rudolf K. Allemann
ChemBioChem, 19, 100-105 (2018). DOI:10.1002/cbic.201700531

2017

Chemo-Enzymatic Assembly of Isotopically Labeled Folates
Antonio Angelastro, William M. Dawson, Louis Y. P. Luk, E. Joel Loveridge and Rudolf K. Allemann
J. Am. Chem. Soc., 139, 13047–13054 (2017). DOI:10.1021/jacs.7b06358

Concise Synthesis of Artemisinin from a Farnesyl Diphosphate Analogue
Xiaoping Tang, Melodi Demiray, Thomas Wirth, and Rudolf K. Allemann
Bioorg. Med. Chem., 19, 100–105 (2017). DOI:10.1016/j.bmc.2017.03.068

A Rapid Analysis of Variations in Conformational Behavior During Dihydrofolate Reductase Catalysis
Robert L. Hughes, Luke A. Johnson, Enas M. Behiry, E. Joel Loveridge, and Rudolf K. Allemann
Biochemistry, 56, 2126–2133 (2017). DOI:10.1021/acs.biochem.7b00045

Reduction of Folate by Dihydrofolate Reductase from Thermotoga maritima
E. Joel Loveridge, Lukas Hroch, Robert L. Hughes, Thomas Williams, Rhidian L. Davies, Antonio Angelastro, Louis Y. P. Luk, Giovanni Maglia and Rudolf K. Allemann
Biochemistry, 56, 1879–1886 (2017). DOI:10.1021/acs.biochem.6b01268

Effiziente chemoenzymatische Synthese von Dihydroartemisinaldehyd
Melodi Demiray, Xiaoping Tang, Juan A. Faraldos, Thomas Wirth and Rudolf K. Allemann
Angew. Chem., 129, 4411–4415 (2017). DOI:10.1002/ange.201609557

An Efficient Chemoenzymatic Synthesis of Dihydroartemisinic Aldehyde
Melodi Demiray, Xiaoping Tang, Juan A. Faraldos, Thomas Wirth and Rudolf K. Allemann
Angew. Chem. Int. Ed., 56, 4347–4350 (2017). DOI:10.1002/anie.201609557

Optimising Terpene Synthesis with Flow Biocatalysis
Xiaoping Tang, Rudolf K. Allemann and Thomas Wirth
Eur. J. Org. Chem., 2, 414–418 (2017). DOI:10.1002/ejoc.201601388 (Video Abstract)

A Versatile Disulfide-driven Recycling System for NADP⁺ with High Cofactor Turnover Number
Antonio Angelastro, William M. Dawson, Louis Y. P. Luk, and Rudolf K. Allemann
ACS Catal., 7, 1025-1029 (2017). DOI:10.1021/acscatal.6b03061
This paper was picked as an ACS Editor’s Choice article and was highlighted in Chemical and Engineering News.

2016

Enzymatic Synthesis of Natural (+)-Aristolochene from a Non-natural Substrate
Juan A. Faraldos, Daniel J. Grundy, Oscar Cascon, Stefano Leoni, Marc W. van der Kamp and Rudolf K. Allemann
Chem Commun., 52, 14027-14030 (2017). DOI:10.1039/C6CC08164A

Azobenzene Photocontrol of Peptides and Proteins
Robert J. Mart and Rudolf K. Allemann
Chem. Commun., 52, 12262-12277 (2016). DOI:10.1039/C6CC04004G

The Amino-terminal Segment in the β-domain of δ-cadinene Synthase is Essential for Catalysis
Verónica González, Daniel J. Grundy, Juan A. Faraldos and Rudolf K. Allemann
Org. Biomol. Chem., 14, 7451-7454 (2016). DOI:10.1039/C6OB01398H

Mechanism of Germacradien-4-ol Synthase-Controlled Water Capture
Daniel J. Grundy, Mengbin Chen, Verónica González, Stefano Leoni, David J. Miller, David W. Christianson and Rudolf K. Allemann
Biochemistry, 55, 2112–2121 (2016). DOI:10.1021/acs.biochem.6b00115

Minimization of Dynamic Effects in the Evolution of Dihydrofolate Reductase
J. Javier Ruiz-Pernía, Enas Behiry, Louis Y. P. Luk, E. Joel Loveridge, Iñaki Tuñón,Vicent Moliner and Rudolf K. Allemann
Chemical Science, 7, 3248-3255 (2016). DOI:10.1039/C5SC04209G

Photocontrolled Exposure of Pro-apoptotic Peptide Sequences in LOV Proteins Modulate Bcl-2 Family Interactions
Robert J. Mart, Dilruba Meah and Rudolf K. Allemann
ChemBioChem, 17, 698–701 (2016). DOI:10.1002/cbic.201500469

Pinpointing Dynamic Coupling in Enzymes for Efficient Drug Design
E. Joel Loveridge and Rudolf K. Allemann
Future Science, 2, FSO95 (2016). DOI:10.4155/fsoa.2015.0017

2015

Conformationally Restricted Calpain Inhibitors
Sarah E. Adams, Emma J. Robinson, David J. Miller, Pierre J. Rizkallah, Maurice B. Hallett and Rudolf K. Allemann
Chemical Science, 6, 6865-6871 (2015). DOI:10.1039/C5SC01158B

Chemical Ligation and Isotope Labeling to Locate Dynamic Effects During Catalysis by Dihydrofolate Reductase
Louis Y. P. Luk, J. Javier Ruiz-Pernía, Aduragbemi S. Adesina, E. Joel Loveridge, Iñaki Tuñón, Vicent Moliner and Rudolf K. Allemann
Angew. Chem. Int. Ed., 54, 9016–9020 (2015). DOI:10.1002/ANIE.201503968

Protein Motions and Dynamic Effects in Enzyme Catalysis
Louis Y. P. Luk, E. Joel Loveridge and Rudolf K. Allemann
Phys. Chem. Chem. Phys., 17 30817-30827 (2015). DOI:10.1039/C5CP00794A

Novel Olfactory Ligands via Terpene Synthases
Sabrina Touchet, Keith Chamberlain, Christine M. Woodcock, David J. Miller, Michael A. Birkett, John A. Pickett and Rudolf K. Allemann
Chem. Commun., 51, 7550-7553 (2015). DOI:10.1039/C5CC01814E

2014

Protein Isotope Effects in Dihydrofolate Reductase from Geobacillus stearothermophilus Show Entropic-Enthalpic Compensatory Effects on the Rate Constant
Louis Y. P. Luk, J. Javier Ruiz-Pernía, William M. Dawson, E. Joel Loveridge, Iñaki Tuñón, Vicent Moliner and Rudolf K. Allemann
J. Am. Chem. Soc., 136, 17317–17323 (2014). DOI:10.1021/ja5102536

Evolutionary and Mechanistic Insights from the Reconstruction of α-Humulene Synthases from a Modern (+)-Germacrene A Synthase
Verónica González, Sabrina Touchet, Daniel J. Grundy, Juan A. Faraldos and Rudolf K. Allemann
J. Am. Chem. Soc., 136, 14505-14512 (2014). DOI:10.1021/ja5066366

The Structural Basis of Differential Inhibition of Human Calpain by Indole and Phenyl Based α-Mercaptoacrylic Acids
Sarah E. Adams, Pierre J. Rizkallah, David J. Miller, Emma J. Robinson, Maurice B. Hallett, Rudolf K. Allemann
J. Struct. Biol., 187, 236-241 (2014). DOI:10.1016/j.jsb.2014.07.004

Role of the Occluded Conformation in Bacterial Dihydrofolate Reductases
Enas M. Behiry, Louis Y. P. Luk, Stella M. Matthews, E. Joel Loveridge and Rudolf K. Allemann
Biochemistry, 53, 4761-4768 (2014). DOI:10.1021/bi500507v

Loop Interactions During Catalysis by Dihydrofolate Reductase from M. profunda
Enas M. Behiry, Rhiannon M. Evans, Jiannan Guo, E. Joel Loveridge and Rudolf K. Allemann
Biochemistry, 53, 4769-4774 (2014). DOI:10.1021/bi500508z

Thermal Adaptation of Dihydrofolate Reductase from the Moderate Thermophile Geobacillus stearothermophilus
Jiannan Guo, Louis Y. P. Luk, E. Joel Loveridge, and Rudolf K. Allemann
Biochemistry, 53, 2855-2863 (2014). DOI:10.1021/bi500238q

Different Dynamical Effects in Mesophilic and Hyperthermophilic Dihydrofolate Reductases
Louis Y. P. Luk, E. Joel Loveridge, and Rudolf K. Allemann
J. Am. Chem. Soc., 136, 6862-6865 (2014). DOI:10.1021/ja502673h

2013

Increased Dynamic Effects in a Catalytically Compromised Variant of Escherichia coli Dihydrofolate Reductase
J. Javier Ruiz-Pernia, Louis Y. P. Luk, Rafael García-Meseguer, Sergio Martí, E. Joel Loveridge, Iñaki Tuñón, Vicent Moliner and Rudolf K. Allemann
J. Am. Chem. Soc., 135, 18689-18696 (2013). DOI:10.1021/ja410519h

Conformational Change and Ligand Binding in the Aristolochene Synthase Catalytic Cycle
Marc W. van der Kamp, Jitnapa Sirirak, Jolanta Zurek, Rudolf K. Allemann and Adrian J. Mulholland
Biochemistry, 52, 8094-8105 (2013). DOI:10.1021/bi400898k

Calpain-1 Inhibitors for Selective Treatment of Rheumatoid Arthritis- What is the Future?
David Miller, Sarah Adams, Maurice B. Hallett, and Rudolf K. Allemann
Future Medicinal Chemistry, 5, 2057-2074 (2013). DOI:10.4155/fmc.13.172

Efficient Terpene Synthase Catalysis by Extraction in Flow
Oscar Cascón, Gerald Richter, Rudolf K. Allemann and Thomas Wirth
ChemPlusChem, 78, 1334-1337 (2013). DOI:10.1002/cplu.201300303

Unraveling the Role of Protein Dynamics in Dihydrofolate Reductase Catalysis
Louis Y. P. Luk, J. Javier Ruiz-Pernía, William M. Dawson, Maite Roca, E. Joel Loveridge, David R. Glowacki, Jeremy N. Harvey, Adrian J. Mulholland, Iñaki Tuñón, Vicent Moliner and Rudolf K. Allemann
Proc. Natl. Acad. Sci., 110, 16344–16349 (2013). DOI:10.1073/pnas.1312437110

The Semiochemistry of Aphids
John A. Pickett, Rudolf K. Allemann and Michael A. Birket
Natural Product Reports, 30, 1277-1283 (2013). DOI:10.1039/C3NP70036D

BH3 Helix-Derived Biophotonic Nanoswitches Regulate Cytochrome c Release in Permeabilised Cells
Robert J. Mart, Rachel J. Errington, Catherine L. Watkins, Sally C. Chappell, Marie Wiltshire, Arwyn T. Jones, Paul J. Smith and Rudolf K. Allemann
Molecular Biosystems, 9, 2597-2603 (2013). DOI:10.1039/C3MB70246D

Mechanistic Insights from the Binding of Substrate and Carbocation Intermediate Analogues to Aristolochene Synthase
Mengbin Chen, Naeemah Al-lami, Marine Janvier, Edward L. D’Antonio, Juan A. Faraldos, David E. Cane, Rudolf K. Allemann and David W. Christianson
Biochemistry, 52, 5441-5453 (2013). DOI:10.1021/BI400691V

Effect of Dimerization on Dihydrofolate Reductase Catalysis,
Jiannan Guo, E. Joel Loveridge, Louis Y.P. Luk and Rudolf K. Allemann
Biochemistry, 52, 3881-3887 (2013). DOI:10.1021/bi4005073

Rational Engineering of Plasticity Residues of Sesquiterpene Synthases from Artemisia annua: Product Specificity and Catalytic Efficiency
Jian-Xu Li, Xin Fang, Qin Zhao, Ju-Xin Ruan, Chang-Qing Yang, Ling-Jian Wang, David J. Miller, Juan A. Faraldos, Rudolf K. Allemann, Xiao-Ya Chen and Peng Zhang
Biochemical J., 451, 417-426 (2013). DOI:10.1042/bj20130041

Strategies for the Manipulation of Carbocations by Aristolochene Synthase
David J. Miller and Rudolf K. Allemann
in Isoprenoid Synthesis in Plants and Microorganisms, New Concepts and Experimental Approaches; pg. 171-183; Bach, Thomas J.; Rohmer, Michel (Eds.), Springer, New York, Heidelberg, Dordrecht, London. ISBN 978-1-4614-4062-8 (2013).

Aliphatic ¹H, ¹³C and ¹⁵N Chemical Shift Assignments of Dihydrofolate Reductase from the Psychropiezophile Moritella profunda in Complex with NADP⁺ and Folate
E. Joel Loveridge, Stella M. Matthews, Christopher Williams, Sara B.-M. Whittaker, Ulrich L. Günther, Rhiannon M. Evans, William M. Dawson, Matthew P. Crump and Rudolf K. Allemann
Biomolecular NMR Assignments, 7, 61-64 (2013). DOI:10.1007/s12104-012-9378-x

2012

Probing the Mechanism of 1,4-Conjugate Elimination Reactions Catalyzed by Terpenoid Synthases
Juan A. Faraldos, Amang Li, Verónica González, Fanglei Yu, Mustafa Köksal, David W. Christianson and Rudolf K. Allemann
J. Am. Chem. Soc., 134, 20844-20848 (2012). DOI:10.1021/ja311022s

¹H, ¹³C and ¹⁵N Chemical Shift Assignments of Unliganded Bcl-x_L and its Complex With a Photoresponsive Bak-derived Peptide
Piotr Wysoczanski, Robert J. Mart, E. Joel Loveridge, Christopher Williams, Sara B.-M. Whittaker, Matthew P. Crump and Rudolf K. Allemann
Biomolecular NMR Assignments.7, 187-191 (2012). DOI:10.1007/s12104-012-9407-9

Chemoenzymatic Preparation of Germacrene Analogues
Oscar Cascón, Sabrina Touchet, David J. Miller, Verónica González, Juan A. Faraldos and Rudolf K. Allemann
Chem. Commun., 48, 9702-9704 (2012). DOI:10.1039/C2CC35542F

Chemoenzymatic Synthesis of the Alarm Pheromone (+)-Verbenone from Geranyl Diphosphate
Zulfa Yoosuf-Aly, Juan A. Faraldos, David J. Miller and Rudolf K. Allemann
Chem. Commun., 48, 7040-7042 (2012). DOI:10.1039/c2cc32883f

NMR Solution Structure of a Photo-switchable Apoptosis Activating Bak Peptide Bound to Bcl-x_L
Piotr Wysoczanski, Robert J. Mart, E. Joel Loveridge, Chris Williams, Sara B.-M. Whittaker, Matthew P. Crump and Rudolf K. Allemann
J. Am. Chem. Soc., 134, 7644-7647 (2012). DOI:10.1021/ja211820p

A 1,6-Ring Closure Mechanism for (+)-δ-Cadinene Synthase?
Juan A. Faraldos, David J. Miller, Verónica González, Zulfa Yoosuf-Aly, Oscar Cascón, Amang Li and Rudolf K. Allemann
J. Am. Chem. Soc., 134, 5900-5908 (2012). DOI:10.1021/ja211820p

Evidence that a ‘Dynamic Knockout’ in Escherichia coli Dihydrofolate Reductase Does Not Affect the Chemical Step of Catalysis
E. Joel Loveridge, Enas M. Behiry, Jiannan Guo and Rudolf K. Allemann
Nature Chemistry., 4, 292-297 (2012). DOI:10.1038/NCHEM.1296

The Role of Aristolchene Synthase in Diphosphate Activation,
Juan A. Faraldos, Verónica González, Rudolf K. Allemann
Chem. Commun., 48, 3230-3232 (2012). DOI:10.1039/C2CC17588F

Design of Photocontrolled RNA-Binding Peptidomimetics
Robert J. Mart,^† Piotr Wysoczanski,^† Sabine Kneissl, Antonio Ricci, Andrea Brancale, Rudolf K. Allemann
ChemBioChem., 13, 515-519 (2012). DOI:10.1002/cbic.201100800

Volatile Emissions of Scented Alstroemeria Genotypes are Dominated by Terpenes, and a Myrcene Synthase Gene is Highly Expressed in Scented Alstroemeria Flowers
Danilo Aros, Verónica González, Rudolf Allemann, Carsten Müller, Carlo Rosat and Hilary Rogers
J. Ex. Bot., 63, 2739-2752. DOI:10.1093/jxb/err456

Potent Inhibition of Ca²⁺-dependent Activation of Calpain-1 by Novel Mercaptoacrylates
Sarah E. Adams, Christian Parr, David J. Miller, Rudolf K. Allemann and Maurice B. Hallett
MedChemComm., 3, 566-570 (2012). DOI:10.1039/C2MD00280A

Sesquiterpene Synthases: Passive Catalysts or Active Players?
David J. Miller and Rudolf K. Allemann
Natural Product Reports, 29, 60-71 (2012). DOI:10.1039/C1NP00060H

2011

The Role of Large-scale Motions in Catalysis by Dihydrofolate Reductase
E. Joel Loveridge, Lai-Hock Tey, Enas M. Behiry, William M. Dawson, Rhiannon M. Evans, Sara B.-M. Whittaker, Ulrich L. Günther, Christopher Williams, Matthew P. Crump and Rudolf K. Allemann
J. Am. Chem. Soc., 113, 20561-20570 (2011). DOI:10.1021/ja208844j

Reduced Susceptibility of Moritella profunda Dihydrofolate Reductase to Trimethoprim is Not Due to Glutamate 28
E. Joel Loveridge, William M. Dawson, Rhiannon M. Evans, Anna Sobolewska and Rudolf K. Allemann
The Protein Journal, 30, 546-548 (2011). DOI:10.1007/s10930-011-9361-x

Chemical Synthesis of Cell-Permeable Apoptotic Peptides from in vivo Produced Proteins
Thomas Fricke, Robert J. Mart, Catherine L. Watkins, Marie Wiltshire, Rachel J. Errington, Paul J. Smith, Arwyn T. Jones and Rudolf K. Allemann
Bioconj. Chem., 22, 1763-1767 (2011). DOI:10.1021/bc200338u

Templating Effects in Aristolochene Synthase Catalysis: Elimination versus Cyclisation
Juan A. Faraldos, Verónica González, Michael Senske and Rudolf K. Allemann
Org. Biomol. Chem., 9, 6920-6923 (2011). DOI:10.1039/c1ob06184d

Probing Eudesmane Cation-π Interactions in Catalysis by Aristolochene Synthase with Non-canonical Amino Acids
Juan A. Faraldos, Alicja K, Antonczak, Verónica González, Rebecca Fullerton, Eric M. Tippmann and Rudolf K. Allemann
J. Am. Chem. Soc., 133 (35), 13906-13609 (2011). DOI:10.1021/ja205927u

Inhibition of (+)-Aristolochene Synthase with Iminium Salts Resembling Eudesmane Cation
Juan A. Faraldos and Rudolf K. Allemann
Org. Lett., 13 (5), 1202-1205 (2011). DOI:10.1021/ol2000843

Effect of pH on Hydride Transfer by Escherichia coli Dihydrofolate Reductase
E. Joel Loveridge and Rudolf K. Allemann
ChemBioChem, 12 (8), 1258-1262 (2011). DOI:10.1002/cbic.201000794

2010

Solvent Effects on Catalysis by Escherichia coli Dihydrofolate Reductase
E. Joel Loveridge, Lai-Hock Tey and Rudolf K. Allemann
J. Am. Chem. Soc., 132 (3), 1137-1143 (2010). DOI: 10.1021/ja909353c

Intermediacy of Eudesmane Cation during Catalysis by Aristolochene Synthase
Juan A. Faraldos, Benson Kariuki and Rudolf K. Allemann
J. Org. Chem., 75 (4), 1119-1125 (2010). DOI: 10.1021/jo902397v

Highly Site-selective Stability Increases by Glycosylation of Dihydrofolate Reductase
Lai-Hock Tey, E. Joel Loveridge, Richard S. Swanwick, Sabine L. Flitsch and Rudolf K. Allemann
FEBS J., 277 (9), 2171-2179 (2010). DOI: 10.1111/j.1742-4658.2010.07634.x

The Temperature Dependence of the Kinetic Isotope Effects of Dihydrofolate Reductase from Thermotoga maritima Is Influenced by Intersubunit Interactions
E. Joel Loveridge and Rudolf K. Allemann
Biochemistry, 49 (25), 5390-5396 (2010). DOI: 10.1021/bi100761x

Regulation of β-Lactamase Activity by Remote Binding of Heme: Functional Coupling of Unrelated Proteins through Domain Insertion
Wayne R. Edwards, Abigail J. Williams, Josephine L. Morris, Amy J. Baldwin, Rudolf K. Allemann and D. Dafydd Jones
Biochemistry, 49 (31), 6541-6549 (2010). DOI: 10.1021/bi100793y

Catalysis by dihydrofolate reductase from the psychropiezophile Moritella profunda
Rhiannon M. Evans, Enas M. Behiry, Lai-Hock Tey, Jiannan Guo, E. Joel Loveridge and Rudolf K. Allemann
ChemBioChem, 11 (14), 2010-2017 (2010). DOI: 10.1002/cbic.201000341

Click Chemistry for the Generation of Cell Permeable Apoptotic Peptides
Thomas Fricke, Robert J. Mart, Catherine L. Watkins, Arwyn T. Jones, Rudolf K. Allemann
Drug Discovery Today, 15 (23-24), 1088 (2010). DOI: 10.1016/j.drudis.2010.09.375

2009

Cystine-based Scaffolds for Functional Miniature Proteins
Rudolf K. Allemann
In RSC Biomolecular Sciences, Oxidative Folding of Proteins and Peptides, (Johannes Buchner and Luis Moroder, Eds.) Royal Society of Chemistry, pp. 381-395 (2009). ISBN: 978-0-85404-148-0.

6- and 14-fluoro farnesyl diphosphate: mechanistic probes for the reaction catalysed by aristolochene synthase
David J. Miller, Fanglei Yu, David W. Knight and Rudolf K. Allemann
Org. Biomol. Chem., 7 (5) 962-975 (2009). DOI: 10.1039/b817194g

Probing coupled motions in enzymatic hydrogen tunnelling reactions
Rudolf K. Allemann, Rhiannon M. Evans and E. Joel Loveridge
Biochem. Soc. Trans., 37, 349-353 (2009) DOI: 10.1042/bst0370349

Quantum Tunnelling in Enzyme Catalyzed Reactions
Rudolf K. Allemann and Nigel S. Scrutton (Eds.), RSC Biomolecular Sciences
Royal Society of Chemistry (2009), ISBN: 978-0-85404-122-0. Buy the book!

Direct methods for the analysis of quantum-mechanical tunnelling: dihydrofolate reductase
E. Joel Loveridge and Rudolf K. Allemann
in RSC Biomolecular Sciences, Quantum Tunnelling in Enzyme Catalyzed Reactions (Rudolf K. Allemann and Nigel S. Scrutton, Eds.), Royal Society of Chemistry, pp. 179-198 (2009).

Different Reaction Mechanisms for Mesophilic and Thermophilic Dihydrofolate Reductases
E. Joel Loveridge, Enas M. Behiry, Richard S. Swanwick and Rudolf K. Allemann
J. Am. Chem. Soc., 131 (20), 6926-6927 (2009). DOI: 10.1021/ja901441k

Effect of Dimerisation on the Stability and Catalytic Activity of Dihydrofolate Reductase from the Hyperthermophile Thermotoga maritima
E. Joel Loveridge, Robert J. Rodriguez, Richard S. Swanwick and Rudolf K. Allemann
Biochemistry, 48 (25), 5922-5933 (2009). DOI: 10.1021/bi900411a

Crystal Structure of (+)-δ-Cadinene Synthase from Gossypium arboreum and Evolutionary Divergence of Metal Binding Motifs for Catalysis
Heather A. Gennadios, Veronica Gonzalez, Luigi Di Costanzo, Amang Li, Fanglei Yu, David J. Miller, Rudolf K. Allemann and David W. Christianson
Biochemistry, 48 (26), 6175-6183 (2009). DOI: 10.1021/bi900483b

Are the catalytic properties of enzymes from piezophilic organisms pressure adapted?
Sam Hay, Rhiannon M. Evans, Colin Levy, E. Joel Loveridge, Xi Wang, David Leys, Rudolf K. Allemann and Nigel S. Scrutton
ChemBioChem, 10 (14) 2348-2353 (2009). DOI: 10.1002/cbic.200900367

The Role of Arginine 28 in Catalysis by Dihydrofolate Reductase from the Hyperthermophile Thermotoga maritima
E. Joel Loveridge, Giovanni Maglia and Rudolf K. Allemann
ChemBioChem, 10 (16) 2624-2627 (2009). DOI: 10.1002/cbic.200900465

2008

Secondary Kinetic Isotope Effects as Probes of Environmentally-Coupled Enzymatic Hydrogen Tunneling Reactions
Sam Hay, Jiayun Pang Phillip J. Monaghan, Xi Wang, Rhiannon M. Evans, Michael J. Sutcliffe, Rudolf K. Allemann and Nigel S. Scrutton
ChemPhysChem, 9, 1536-1539 (2008). DOI: 10.1002/cphc.200800291

Stereochemistry of Eudesmane Cation Formation During Catalysis by Aristolochene Synthase from Penicillium roqueforti
David J. Miller, Jiali Gao, Donald G. Truhlar, Neil J. Young, Veronica Gonzalez and Rudolf K. Allemann
Org. Biomol. Chem., 6, 2346-2354 (2008). DOI: 10.1039/b804198a

X-ray crystallographic studies of substrate binding to aristolochene synthase suggest a metal binding sequence for catalysis
Katerina Y. Shishova, Fanglei Yu, David J. Miller, Juan A. Faraldos, Yuxin Zhao, Robert M. Coates, Rudolf K. Allemann, David E. Cane, and David W. Christianson
J. Biol. Chem., 283, 15431-15439 (2008). DOI: 10.1074/jbc.M800659200

Differential Specific Radiation Damage in the Cu(II)- and Pd(II)-bound Forms of an α-Helical Foldamer: A Case Study of Crystallographic Phasing by RIP and SAD
Klaus Fütterer, Raimond B. G. Ravelli, Scott A. White, Andrew J. Nicoll, Rudolf K. Allemann
Acta Cryst. D, 64, 264-272 (2008).DOI: 10.1107/S0907444907065948

Linking the Functions of Unrelated Proteins Using a Novel Directed Evolution Domain Insertion Method
Wayne R. Edwards, Kathy Busse, Rudolf K. Allemann and D. Dafydd Jones
Nucl. Acid Res., 36, e78 (2008). DOI: 10.1093/nar/gkn363

Chemical Wizardry? The Generation of Chemical Diversity in Terpenoid Biosynthesis
Rudolf K. Allemann
Pure Appl. Chem., 80,1791-1798 (2008). DOI: 10.1351/pac200880081791

Solvent Effects on Environmentally Coupled Hydrogen Tunnelling During Catalysis by Dihydrofolate Reductase from Thermotoga maritima
E. Joel Loveridge, Rhiannon M. Evans and Rudolf K. Allemann
Chem. Eur. J., 14, 10782-10788 (2008). DOI: 10.1002/chem.200801804

Peptide-Based Biophotonic Nanoswitches Act as Antagonists of Anti-Apoptotic Bcl-xL
Sabine Kneissl, E. Joel Loveridge, Christopher Williams, Matthew P. Crump and Rudolf K Allemann
ChemBioChem, 9, 3046-3055 (2008). DOI: 10.1002/cbic.200800502

2007

Molecular Dynamics Simulations of the Thermal Unfolding of Thermotoga maritima DHFR
Jiayun Pang and Rudolf K. Allemann
Phys. Chem. Chem. Phys., 9, 718 (2007). DOI: 10.1039/B611210B

myo-Inositol Monophosphate: A Challenging Target for Mood Stabilising Drugs
D.J. Miller and Rudolf K. Allemann
Mini-Reviews in Medicinal Chemistry , 7, 107 (2007). DOI: 10.2174/138955707779802624

Aristolochene Synthase-Catalyzed Cyclization of 2-Fluorofarnesyl-Diphosphate to 2-Fluorogermacrene A
David J. Miller, Fanglei Yu and Rudolf K. Allemann
ChemBioChem, 2007, 15(8), 1819-1825. DOI: 10.1002/cbic.200700219

Probing the Reaction Mechanism of Aristolochene Synthase with 12,13-Difluorofarnesyl Diphosphate
Fanglei Yu, David J. Miller and Rudolf K. Allemann
Chem. Commun., 2007, 40, 4155-4157. DOI: 10.1039/b709562g

Synthetic Efficiency in Enzyme Mechanisms Involving Carbocations: Aristolochene Synthase
Rudolf K. Allemann, Neil J. Young, Shuhua Ma, Donald G. Truhlar, Jiali Gao
J. Am. Chem. Soc, 129, 13008-13013 (2007). DOI: 10.1021/ja0722067

Competitive Inhibition of Aristolochene Synthase by Phenyl-Substituted Farnesyl Diphosophates: Evidence of Active Site Plasticity
David J. Miller, Fanglei Yu, Neil J. Young and Rudolf K. Allemann
Org. Biomol. Chem., 2007, 5, 3287-3298 DOI: 10.1039/B713301B

2006

Coupling of Protein Motions and Hydrogen Transfer during Catalysis by Escherichia coli Dihydrofolate Reductase
Richard Swanwick, Giovanni Maglia, Lai-Hock Tey and Rudolf K. Allemann
Biochem. J., 394, 259-265 (2006). DOI:10.1042/BJ20051464

Hydride Transfer Reaction Catalyzed by Hyperthermophilic Dihydrofolate Reductase is Dominated by Quantum Mechanical Tunneling and is Promoted by Both Inter- and Intramonomeric Correlated Motions
Jiayun Pang, Jingzhi Pu, Jiali Gao, Donald G. Truhlar, and Rudolf K. Allemann
J. Am. Chem. Soc,128 (24), 8015-8023 (2006). DOI:10.1021/ja061585l

Stabilisation of Transition States Prior to and Following Eudesmane Cation in Aristolochene Synthase
Silvia Forcat and Rudolf K. Allemann
Org. Biomol. Chem., (13), 2563-2567 (2006). DOI:10.1039/b604147g

Designed High Affinity Cu²⁺-Binding α-Helcal Foldamer
Andrew J. Nicoll, David J. Miller, Klaus Fütterer, Raymond Ravelli and Rudolf K. Allemann
J. Am. Chem. Soc, 128, 9187-9193 (2006). DOI:10.1021/ja061513u

Protein Motions during Catalysis by Dihydrofolate Reductases
Rudolf K. Allemann, Rhiannon M. Evans, Lai-Hock Tey, Giovanni Maglia, Jiayun Pang, Robert J. Rodriguez, Paul J. Shrimpton and Richard S. Swanwick
Phil. Trans. Roy. Soc. B, 361, 1317-1321 (2006). DOI:10.1098/rstb.2006.1865

2005

Photocontrol of Specificity of a Miniature Engrailed Homoeodomain
Lucia Guerrero, Oliver S. Smart, G. Andrew Woolley and Rudolf K. Allemann
J. Am. Chem. Soc., 127, 15624-15629, (2005). DOI:10.1021/ja0550428

De novo Design of a Stable N-terminal Helical Foldamer
Andrew J. Nicoll, Christopher J. Weston, Charlotte H. Cureton, Christian Ludwig, Felican Dancea, Neil Spencer Oliver S. Smart, Ulrich L. Günther and Rudolf K. Allemann
Org. Biomol. Chem., 3, 4310-4315 (2005). DOI:10.1039/b513891d

Photoregulation of DNA Binding Dpecificity by MyoD
Lucia Guerrero, Oliver S. Smart, Christopher J. Weston, Darcy C. Burns, G. Andrew Woolley and Rudolf K. Allemann
Angew. Chem., 44, 7778-7782 (2005). DOI:10.1002/anie.200502666

Increased Thermal Stability of Glycosylated Dihydrofolate Reductase
Richard S. Swanwick, Alison M. Daines, Lai-Hock Tey, Sabine L. Flitsch and Rudolf K. Allemann
ChemBioChem, 8, 1338-1340 (2005). DOI:10.1002/cbic.200500103

Synthesis of Homogeneous Site-Selectively Glycosylated Proteins
Richard S. Swanwick, Alison M. Daines, Sabine L. Flitsch and Rudolf K. Allemann
Org. Biomol. Chem., 3, 572-574 (2005). DOI:10.1039/b417133k

2004

Controlling the DNA Binding Specificity of bHLH Proteins through Intramolecular Interactions
Elizabeth C. Turner, Charlotte H. Cureton, Christopher J. Weston, Oliver S. Smart, and Rudolf K. Allemann
Chem. Biol., 11, 69-77 (2004). DOI:10.1016/j.chembiol.2003.12.015

Bis-Benzyl Protected 6-Amino Cyclitols are Poisonous to Pd/C Catalysed Hydrogenolysis of Benzyl Ethers
M. Bashir-Uddin Surfraz, Mahmoud Akhtar and Rudolf K. Allemann
Tet. Lett., 45, 1223-1226 (2004).DOI:10.1016/j.tetlet.2003.11.130

Removal of the Phosphate Group in Mechanism-based Inhibitors of Inositol Monophosphatase Leads to Unusual Inhibitory Activity
David J. Miller, M. Bashir-Uddin Surfraz, Mahmoud Akhtar, David Gani and Rudolf K. Allemann
Org. Biomol. Chem., 2, 671-688 (2004). DOI:10.1039/b312808c

Pivotal Role of Gly 121 in Dihydrofolate Reductase from E. coli: Altered Structure of a Mutant Enzyme May Form Basis of Diminished Catalytic Performance
Richard S. Swanwick, Paul J. Shrimpton, and Rudolf K. Allemann
Biochemistry, 43, 4119-4127 (2004). DOI:10.1021/bi036164k

A Stable Miniature Protein with Oxaloacetate Decarboxylase Activity
Christopher J. Weston, C. H. Cureton, Melanie J. Calvert, Oliver S. Smart and Rudolf K. Allemann
Chem. Biochem., 5, 1075-1080 (2004). DOI:10.1002/cbic.200300805

Nucleophilic and General Acid Catalysis at Physiological pH by a Designed Miniature Esterase
Andrew J. Nicoll and Rudolf K. Allemann
Org. Biomol. Chem, 2, 2175-2180 (2004). DOI:10.1039/b404730c

Dual Role for Phenylalanine 178 during Catalysis by Aristolochene Synthase
Silvia Forcat and Rudolf K. Allemann
Chem. Comm., 2094-2095 (2004). DOI:10.1039/b407932a

Miniature Proteomics: Designing Functional α-Helical Miniature Proteins
Andrew J. Nicoll and Rudolf K. Allemann
Rec. Res. Dev. Chem., 2, 227-243 (2004).

2003

Functional Role for Tyr 31 in the Catalytic Cycle of Chicken Dihydrofolate Reductase
Paul J. Shrimpton, Alex Mullaney and Rudolf K. Allemann
Prot. Struct. Funct. Genet. 51, 216-223 (2003).DOI:10.1002/prot.10370

Structure-Activity Relationship of Human Serum Paraoxonase PON1
Rakesh S. Bargota, Mahmoud Akhtar, Keith Biggadike, David Gani and Rudolf K. Allemann
Bioorg. Med. Chem. Lett. 13, 1623-1626 (2003). DOI:10.1016/S0960-894X(03)00290-7

Evidence for Differential Folding of Farnesylpyrophosphate in the Active Site of Aristolochene Synthase: Single Point Mutation Converts Aristolochene Synthase into a (E)-Beta-Farnesene Synthase
Athina Deligeorgopoulou and Rudolf K. Allemann
Biochemistry, 42, 7741-7747 (2003). DOI:10.1021/bi034410m

Hydride Transfer during Catalysis by Dihydrofolate Reductase from Thermitoga maritima
Giovanni Maglia, Masood H. Javed and Rudolf K. Allemann
Biochem. J., 374, 529-535 (2003).DOI:10.1042/BJ20030412

Stabilisation of Eudesmane Cation by Tryptophan 334 During Aristolochene Synthase Catalysis
Athina Deligeorgopoulou, Silvia Forcat, Susan E. Taylor and Rudolf K. Allemann
Chem. Comm., 2162-2163 (2003). DOI:10.1039/b306867f

Product like Inhibitors of Inositol Monophosphatase
M. Bashir-Uddin Surfraz, David J. Miller, David Gani and Rudolf K. Allemann
Tet. Lett., 43 (41), 7677-7679 (2003). DOI:10.1016/S0040-4039(03)01878-1

Evidence for Environmentally Coupled Hydrogen Tunnelling During Dihydrofolate Reductase Catalysis
Giovanni Maglia and Rudolf K. Allemann
J. Am. Chem. Soc., 125, 13372-13373 (2003). DOI:10.1021/ja035692g

2002

Design of a Folded, Conformationally Stable Oxaloacetate Decarboxylase
Susan E. Taylor, Trevor J. Rutherford and Rudolf K. Allemann
Perkin Trans. 2, 751-755 (2002). DOI:10.1039/b200057c

Role of Water in the Catalytic Cycle of E. coli Dihydrofolate Reductase
Paul J. Shrimpton and Rudolf K. Allemann
Prot. Sci., 11, 1442-1451 (2002). DOI:10.1110/ps.5060102

Germacrene A is a Product of the Aristolochene Synthase Mediated Conversion of Farnesylpyrophosphate to Aristolochene
Melanie J. Calvert, Peter. R. Ashton and Rudolf K. Allemann
J. Am. Chem. Soc., 124, 11636-11641 (2002). DOI:10.1021/ja020762p

Tyrosine 92 of Aristolochene Synthase Directs Cyclisation of Farnesyl-Pyrophosphate
Melanie J. Calvert, Susan E. Taylor and Rudolf K. Allemann
Chem. Comm., 2384-2385 (2002). DOI:10.1039/b206517g

2001

Synthesis and Characterisation of a Peptide with Oxaloacetate Decarboxylase Activity
Susan E. Taylor, Trevor J. Rutherford and Rudolf K. Allemann, Design
Bioorg. Med. Chem. Lett., 11, 2631-2635 (2001). DOI:10.1016/S0960-894X(01)00519-4

2000

Thermodynamics of DNA Binding Reaction of MM17, a Single Chain Dimer of Transcription Factor MASH-1
Martin Sieber and Rudolf K. Allemann
Nucl. Acids Res., 28, 2122-2127 (2000). DOI:10.1093/nar/28.10.2122

1999

Transcription Factors
Rudolf K. Allemann
Encyclopedia of Molecular Biology, T. E. Creighton (ed.), Wiley, pp. 2586-2593 (1999).

Acquisition of Myogenic Specificity Through Replacement of Two Amino Acid Residues of MASH-1 and Introduction of One Additional alpha-Helical Turn
C. Dezan, Daniel Meierhans, Andreas G. E. Künne and Rudolf K. Allemann
Biol. Chem., 380, 705-710 (1999). DOI:10.1515/BC.1999.088

1998

Single Chain Dimers of MASH-1 Bind DNA with Enhanced Affinity
Martin Sieber and Rudolf K. Allemann
Nucl. Acids Res., 26, 1408-1413 (1998). DOI: 10.1093/nar/26.6.1408

Thermodynamics of the DNA Binding Reaction of Transcription Factor MASH-1
Andreas G. E. Künne, Martin Sieber, Daniel Meierhans and Rudolf K. Allemann
Biochemistry, 37, 4217-4223 (1998). DOI:10.1021/bi9725374

Arginine 348 is a Major Determinant of the DNA Binding Specificity of Transcription Factor E12
Martin Sieber and Rudolf K. Allemann
Biol. Chem., 379, 731-735 (1998). DOI:10.1515/bchm.1998.379.6.721

The N-Terminal Methionine is a Major Determinant of the DNA Binding Specificity of MEF-2C
Daniel Meierhans and Rudolf K. Allemann
J. Biol. Chem., 273, 26052-26060 (1998). DOI:10.1074/jbc.273.40.26052

1997

Covalently Linking MASH-1 BHLH Subunits Enhances Specificity of DNA Binding
Andreas G. E. Künne, and Rudolf K. Allemann
Biochemistry, 36, 1085-1091 (1997). DOI:10.1021/bi962185l

High Level Expression in Soluble Form, One Step Purification, and Characterisation of DNA Binding Domain of MEF-2C
Daniel Meierhans and Rudolf K. Allemann
Prot. Express. Purif., 11, 297-303 (1997). DOI:10.1006/prep.1997.0795

DNA Recognition and Bending
Rudolf K. Allemann and Martin Egli
Chem. Biol., 4, 643-650 (1997). DOI:10.1016/S1074-5521(97)90218-0

High Affinity Binding of MEF-2C depends on DNA Bending
Daniel Meierhans, Martin Sieber and Rudolf K. Allemann
Nucl. Acids Res., 25, 4537-4544 (1997). DOI:10.1093/nar/25.22.4537

1996

MyoD Displays Modest DNA Binding Specificity
Andreas G. E. Künne, Daniel Meierhans and Rudolf K. Allemann
FEBS Lett., 391, 79-83 (1996). DOI:10.1016/0014-5793(96)00707-7

1995

DNA Binding Specificity of the Basic-Helix-Loop-Helix Protein MASH-1
Daniel Meierhans, Chirine el Ariss, Margrit Neuenschwander, Martin Sieber, Joseph F. Stackhouse and Rudolf K. Allemann
Biochemistry, 34, 11026-11036 (1995). DOI:10.1021/bi00035a008

1993

Design, Synthesis, Structure Analysis, and Catalytic Activity of Oxaldie: An Artificial Enzyme with Nature-like Structure
Kai Johnson, Rudolf K. Allemann, Hans Widmer and Steven A. Benner
Nature, 365, 530-532 (1993). DOI:10.1038/365530a0

1991

A Hybrid of Bovine Pancreatic Ribonuclease and Human Angiogenin: An External Loop as a Module Controlling Substrate Specificity?
Rudolf K. Allemann, Scott R. Presnell and Steven A. Benner
Prot. Eng. 4, 831-835 (1991). DOI:10.1093/protein/4.7.831

Multiple Spatially-Specific Enhancers are Required to Reconstruct the Pattern of Hox-2.6 Gene Expression
Jenny Whiting, Heather Marshall, Martyn Cook, Robb Krumlauf, Peter W. J. Rigby, David Stott, and Rudolf K. Allemann
Genes and Development 5, 2048-2059 (1991). DOI:10.1101/gad.5.11.2048

1989

The Return of Pancreatic Ribonucleases
Steven A. Benner and Rudolf K. Allemann
Trend. Biochem. Sci., 14 (10), 396 (1989). DOI:10.1016/0968-0004(89)90282-X

1988

A Stereochemical Profile of the Dehydrogenases of Drosophila melanogaster
Rudolf K. Allemann, Rebecca Hung and Steven A. Benner
J. Am. Chem. Soc., 110, 5555-5560 (1988). DOI:10.1021/ja00224a046