Publications

Independent Research (Cardiff University):

  1. Frustrated Lewis Pair (FLP)-Catalyzed Hydrogenation of Aza-Morita-Baylis-Hillman Adducts and Sequential Organo-FLP Catalysis”, I. Khan, M. Manzotti, G. J. Tizzard, S. J. Coles, R. L. Melen* and L. C. Morrill*, ACS Catal., 2017, 7, 7748-7752. [link]

  1. “Deoxycyanamidation of Alcohols with N-Cyano-N-Phenyl-p-Methylbenzenesulfonamide (NCTS)”, J. N. Ayres, M. W. Ashford, Y. Stöckl, V. Prudhomme, K. B. Ling, J. A. Platts and L. C. Morrill*, Org. Lett., 2017, 19, 3835-3838. [link]

  1. “N-Cyanation of Secondary Amines using Trichloroacetonitrile”, J. N. Ayres, K. B. Ling* and L. C. Morrill*, Org. Lett., 2016, 18, 5528-5531. [link]

Postdoctoral Research (UC Berkeley with Prof. Richmond Sarpong):

  1. A Magnesiate Addition/Ring-Expansion Strategy to Access the 6-7-6 Tricyclic Core of Hetisine-type C20-Diterpenoid Alkaloids”, J. J. Pflueger, L. C. Morrill, J. N. deGruyter, M. A. Perea and R. Sarpong*, Org. Lett., 2017, 19, 4632-4635. [link]
  2. “Palladium-catalyzed β-Selective C(sp3)-H Arylation of N-Boc-Piperidines”, A. Millet and O. Baudoin*; checked by L. C. Morrill and R. Sarpong, Org. Synth., 2015, 92, 76-90. [link]

Graduate Research (University of St Andrews with Prof. Andrew D. Smith):

  1. “Enantioselective Synthesis of 3,5,6-Substituted Dihydropyranones and Dihydropyridinones using Isothiourea-Mediated Catalysis”, D. G. Stark, L. C. Morrill, D. B. Cordes, A. M. Z. Slawin, T. J. C. O’Riordan and A. D. Smith*, Chem. Asian J., 2016, 11, 395-400. [Special Issue: Catalysis and Transformation of Complex Molecules] [link]
  2. “Asymmetric Isothiourea-Catalysed Formal [3+2] Cycloadditions of Ammonium Enolates with Oxaziridines”S. R. Smith, C. Fallan, J. E. Taylor, R. McLennan, D. S. B. Daniels, L. C. Morrill, A. M. Z. Slawin and A. D. Smith*, Chem. Eur. J., 2015, 21, 10530-10536. [link]
  3. “Organocatalytic Michael Addition-Lactonisation of Carboxylic Acids using α,β-Unsaturated Trichloromethyl Ketones as α,β-Unsaturated Ester Equivalents”, L. C. Morrill, D. G. Stark, J. E. Taylor, S. R. Smith, J. A. Squires, A. C. A. D’Hollander, C. Simal, P. Shapland, T. J. C. O’Riordan and A. D. Smith*, Org. Biomol. Chem., 2014, 12, 9016-9027. [link] [Highlighted in Synfacts2015, 11, 315] [link] [Part of themed collection: 2014 Hot Articles in Organic and Biological Chemistry] [link]
  4. “Isothiourea-Mediated Asymmetric Functionalization of 3-Alkenoic Acids”, L. C. Morrill, S. M. Smith, A. M. Z. Slawin and A. D. Smith*, J. Org. Chem., 2014, 79, 1640-1655[link]
  5. “2-Arylacetic anhydrides as ammonium enolate precursors”, L. C. Morrill, L. A. Ledingham, J-P. Couturier, J. Bickel, A. Harper, C. Fallan and A. D. Smith*, Org. Biomol. Chem., 2014, 12, 624-636. [link]
  6. “Isothiourea-Mediated One-Pot Synthesis of Functionalized Pyridines”, D. G. Stark, L. C. Morrill, P-P. Yeh, A. M. Z. Slawin, T. J. C. O’Riordan and A. D. Smith*, Angew. Chem. Int. Ed., 2013, 52, 11642-11646. [Selected as a Hot Paper] [link] [Highlighted in Synfacts, 2013, 9, 1344] [link] [Highlighted in Org. Chem. Highlights, 2014, June 23]. [link]
  7. “Stereospecific Asymmetric N-Heterocyclic Carbene (NHC)-Catalyzed Redox Synthesis of Trifluoromethyl Dihydropyranones and Mechanistic Insights”, A. T. Davies, J. E. Taylor, J. Douglas, C. J. Collett, L. C. Morrill, C. Fallan, A. M. Z. Slawin and A. D. Smith*, J. Org. Chem., 2013, 78, 9243-9257. [link]
  8. “Isothiourea-mediated asymmetric Michael-lactonisation of trifluoromethylenones: a synthetic and mechanistic study”, L. C. Morrill, J. Douglas, T. Lebl, D. J. Fox, A. M. Z. Slawin and A. D. Smith*, Chem. Sci., 2013,4, 4146-4155. [One of the most accessed articles in Chem. Sci. during August 2013]. [link] [Part of themed collection: Celebrating the 2014 RSC Prize and Award Winners] [link]
  9. “Catalytic asymmetric α-amination of carboxylic acids using isothioureas”, L. C. Morrill, T. Lebl, A. M. Z. Slawin and A. D. Smith*, Chem. Sci., 2012, 3, 2088-2093. [link]
  10. “Organocatalytic Functionalisation of Carboxylic Acids: Isothiourea-Catalysed Asymmetric Intra- and Intermolecular Michael Addition-Lactonisations”, D. Belmessieri, L. C. Morrill, C. Simal, A. M. Z. Slawin and A. D. Smith*, J. Am. Chem. Soc., 2011, 133, 2714-2720. [link] [Highlighted in Synfacts, 2011, 4, 436]. [link]

Undergraduate Research (University of St Andrews):

  1. “Regiodivergent Lewis base-promoted O- to C-carboxyl transfer of furanyl carbonates”, C. D. Campbell, C. Joannesse, L. C. Morrill, D. Philp and A. D. Smith*, Org. Biomol. Chem., 2015, 13, 2895-2900. [link] [Part of themed collection: 2015 Hot Articles in Organic and Biomolecular Chemistry] [link]
  2. “Efficacious, inhaled PDE4 inhibitors with low emetic potential and long duration of action, for the treatment of COPD”, C. De Savi*, R. J. Cox*, D. Warner, A. R. Cook, M. R. Dickinson, A. McDonough, L. C. Morrill, B. Parker, G. Andrews, S. Young, P. S. Gilmour, R. Riley and M. S. Dearman, J. Med. Chem., 2014, 57, 4661-4676[link]
  3. “Isothiourea-Mediated Asymmetric O- to C-Carboxyl Transfer of Oxazoyl Carbonates: Structure-Selectivity Profiles and Mechanistic Studies”, C. Joannesse, C. P. Johnston, L. C. Morrill, P. A. Woods, M. Kieffer, T. A. Nigst, H. Mayr, T. Lebl, D. Philp, R. A. Bragg and A. D. Smith*, Chem. Eur. J., 2012, 18, 2398-2408. [link]
  4. “Isothiourea-Catalyzed Asymmetric C-Acylation of Silyl Ketene Acetals”, P. A. Woods, L. C. Morrill, R. A. Bragg and A. D. Smith*, Chem. Eur. J., 2011, 17, 11060-11067. [link]
  5. “Isothiourea-catalyzed asymmetric O- to C-carboxyl transfer of furanyl carbonates”, C. Joannesse, L. C. Morrill, C. D. Campbell, A. M. Z. Slawin and A. D. Smith*, Synthesis, 2011, 1865-1879. [link]
  6. “Isothiourea-Mediated Stereoselective C-acylation of Silyl Ketene Acetals”, P. A. Woods, L. C. Morrill, T Lebl, A. M. Z. Slawin, R. A. Bragg and A. D. Smith*, Org. Lett., 2010, 12, 2660-2663. [link]
  7. “Unexpected Rearrangement Leading to Formation of a 1,3-Bis(triphenylphosponio)prop-1-en-3-idyl Carboxylate”, R. A. Aitken*, L. P. Cleghorn, R. M. Leitch, L. C. Morrill and A. M. Z. Slawin, Eur. J. Org. Chem., 2010, 3211-3214. [link]
  8. “N-heterocyclic carbene catalysed O- to C-carboxyl transfer of indolyl and benzofuranyl carbonates”, J. E. Thomson, A. F. Kyle, C. Concellón, K. A. Gallagher, P. Lenden, L. C. Morrill, A. J. Miller, C. Joannesse, A. M. Z. Slawin and A. D. Smith*, Synthesis, 2008, 2805-2818. [link]

Book Chapters and Review Articles:

  1. “Catalytic Generation of Ammonium Enolates and Related Tertiary Amine-Derived Intermediates: Applications, Mechanism and Stereochemical Models (n→π*)”, K. N. Van, L. C. Morrill, A. D. Smith and D. Romo, Book Chapter within “Lewis Base Catalysis in Organic Synthesis”, ed. E. Vedejs and S. E. Denmark, Wiley, Weinheim, 2016. [link]
  2. “Organocatalytic Lewis base functionalisation of carboxylic acids and esters via ammonium/azolium enolates”, L. C. Morrill and A. D. Smith*, Chem. Soc. Rev., 2014, 43, 6214-6226. [One of the most accessed articles in Chem. Soc. Rev. during June 2014]. [link]
  3. “Lewis Base Catalysed Asymmetric [2+2] Cycloadditions”, A. D. Smith, J. Douglas, L. C. Morrill and E. Richmond, Book Chapter within “Methods and Applications of Cycloaddition Reactions in Organic Synthesis” , ed. N. Nishiwaki, Wiley, New York, 2014. [link]