Chemical biology is the application of chemical techniques to solve biological problems. In the Allemann laboratories we apply a range of chemical techniques to answer questions relating to the extraordinary catalytic power of enzymes and the control of biological processes.
We are always seeking bright and highly motivated students and postdocs to join our dynamic, multidisciplinary research group to work on any of our current projects. Informal enquiries are welcome. If you are interested in joining the Allemann Laboratories, click here for a list of vacancies.
Our recent publication in Chemical Science describes new conformationally restrained inhibitors for calpain I, an enzyme linked to inflammation, autoimmune diseases and many other conditions. Our results suggest the the mercaptoacrylate group previously found to be important for activity may act as a dimerising motif.
Our paper in Angewandte Chemie describe how building enzymes from various isotopically labelled 'heavy' and natural abundance 'light' building blocks can help locate the source of dynamic effects during catalysis.