Cartoon of an FPP-derived inhibitor in the active site of a terpene cyclase


Chemical biology is the application of chemical techniques to solve biological problems. In the Allemann laboratories we apply a range of chemical techniques to answer questions relating to the extraordinary catalytic power of enzymes and the control of biological processes.

We are always seeking bright and highly motivated students and postdocs to join our dynamic, multidisciplinary research group to work on any of our current projects. Informal enquiries are welcome. If you are interested in joining the Allemann Laboratories, click here for a list of vacancies.


Our new publication in Biochemistry explores the mechanism of germacradien-4-ol synthase. This enzyme is unusual because water is usually rigorously excluded from the active site to protect the reactive carbocation species. Germacradien-4-ol synthase allows the carbocation to be quenched by water, but with complete selectivity.

Our new paper in Chemical Science examines the kinetic parameters of dihydrofolate reductase enzymes from different organisms. Whilst some have suggested that dynamic coupling is a key tool for explaining enzyme activity, our results suggests that evolution has actually minimised dynamic effects.

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