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Cartoon of an FPP-derived inhibitor in the active site of a terpene cyclase


Chemical biology is the application of chemical techniques to solve biological problems. In the Allemann laboratories we apply a range of chemical techniques to answer questions relating to the extraordinary catalytic power of enzymes and the control of biological processes.

We are always seeking bright and highly motivated students and postdocs to join our dynamic, multidisciplinary research group to work on any of our current projects. Informal enquiries are welcome. If you are interested in joining the Allemann Laboratories, click here for a list of vacancies.


Our recent publication in the Journal of the American Chemical Society gives insight into the evolutionary history of plant enzymes. The paper shows how changing a single amino acid of an enzyme alters the product distribution from 10 to 11-membered carbocycles, suggesting that these different classes of terpene cyclases may share a common ancestor.

We welcome Chris Jones and Robert Hughes to the group! Chris will join our terpene cyclase research team while Rob will work on new substrates for our enzyme mechanisms project.

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